Infectious Disease

Combination Therapies

Treatments that use two or more medications together to improve effectiveness against infections.

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What are Combination Therapies? 

Combination therapies involve using different drugs at the same time to treat infectious diseases. By targeting the infection in multiple ways, they increase effectiveness, lower the chance of resistance, and improve patient outcomes. Common examples include HIV treatment with multiple antiretrovirals or tuberculosis therapy with several antibiotics. 

This treatment helps to: 

  • Increase effectiveness compared to single-drug therapy 
  • Reduce the risk of drug resistance 
  • Control complex or chronic infections like HIV or TB 
  • Shorten treatment duration in some cases 
  • Improve long-term patient outcomes 

What to expect during treatment? 

Patients may take multiple medications daily, sometimes for long periods. 

  • Better infection control and symptom relief 
  • Possible mild side effects such as nausea or fatigue 
  • Careful monitoring to adjust doses and manage interactions 
  • Regular follow-ups to ensure treatment success 

Why is it performed?

  • To manage infections known for resistance, like HIV and TB
  • To improve cure rates in serious infections
  • To treat mixed or complicated infections
  • To prevent relapse and recurrence

Risks and Considerations

  • Higher chance of side effects due to multiple drugs
  • Possible interactions with other medications
  • Need for strict adherence to avoid resistance
  • Some regimens may be long or complex

Early detection is important for managing the condition and preventing further complications.

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FAQs

Why use more than one drug?
It attacks the infection in different ways, making treatment more effective.
Sometimes, but simplified regimens and support make adherence easier.
It depends on the infection—weeks for TB, lifelong for HIV.
If you miss doses, have severe side effects, or notice worsening symptoms.
Missing doses can reduce effectiveness and promote drug resistance; contact your healthcare team for immediate guidance and follow their missed-dose instructions.

Doral Health & Wellness Infection Control Department

Doral Health & Wellness Infectious Disease specializes in the diagnosis and treatment of a wide range of infectious diseases, including bacterial, viral, fungal, and parasitic infections. Our expert team provides comprehensive care, including advanced diagnostics, personalized treatment plans, and ongoing support to help you recover and thrive.

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